Cell Signaling Thyroid Transcription Factor 1 (Ttf-1) (Spt24) Mouse mAb

Name: Cell Signaling Thyroid Transcription Factor 1 (Ttf-1) (Spt24) Mouse mAb
SKU: CSIG-23192S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Thyroid Transcription Factor 1 (Ttf-1) (Spt24) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-23192S

MFG.PART: 23192S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 ul
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{IHC Leica Bond: 1:100 - 1:400, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	Thyroid Transcription Factor 1 (TTF-1) (SPT24) Mouse mAb recognizes endogenous levels of TTF-1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of human TTF-1 protein.
Background	Thyroid Transcription Factor 1 (TTF-1, also known as NKX2-1), a member of the NKX homeobox transcription factor family, was initially discovered in the FRTL-5 rat thyroid cell line (1). Subsequent studies have shown that TTF-1 plays an important role in differentiation and morphogenesis of the developing thyroid, lung, and ventral forebrain (2). TTF-1 controls the expression of several genes, some of which are tissue specific, such as: thyroglobulin, thyroperoxidase, and the thyrotropin receptor in the thyroid; and surfactant proteins and clara cell secretory protein in the lung (2,3). Investigators have found that TTF-1 is expressed in malignant tumors of the thyroid and lung, and it is commonly used as a marker for both primary and malignant lung cancers (4-6).

Specifications