Cell Signaling Phospho-Mapk/Cdk Substrates (PxsP Or SPxr/K) (34b2) Rabbit mAb

Name: Cell Signaling Phospho-Mapk/Cdk Substrates (Pxs*P Or S*Pxr/K) (34b2) Rabbit mAb
SKU: CSIG-2325S
Price: 419.15 USD

List Price $419.15 Your Price $419.15

Cell Signaling Phospho-Mapk/Cdk Substrates (Pxs*P Or S*Pxr/K) (34b2) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2325S

MFG.PART: 2325S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:200, Peptide ELISA (DELFIA): 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-MAPK/CDK Substrates (PXSP or SPXR/K) (34B2) Rabbit mAb detects phospho-serine in a PXSP or SPXR/K motif, as well as a PXS*PXR/K motif. The antibody is phospho-specific, and does not react with phospho-threonine- or phospho-tyrosine-containing peptides/proteins.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with synthetic phospho-MAPK/CDK substrate peptides .
Background	The MAPK and CDK families of serine/threonine protein kinases play important roles in proliferation and cell cycle control. These kinases phosphorylate threonine or serine followed by a proline residue (1-3). MAPK phosphorylates substrates with the consensus sequence PX(S/T)P, and CDKs phosphorylate substrates containing the consensus sequence (S/T)PXR/K. Cell Signaling Technology has developed antibodies that bind to phospho-threonine followed by proline, motifs PXS/TP and/or S*PXR/K, for use in the study and discovery of new MAPK and CDK substrates (4,5).

Cell Signaling Phospho-Mapk/Cdk Substrates (Pxs*P Or S*Pxr/K) (34b2) Rabbit mAb