Cell Signaling Cox10 (E6k4d) Rabbit mAb

Name: Cell Signaling Cox10 (E6k4d) Rabbit mAb
SKU: CSIG-24744S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cox10 (E6k4d) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-24744S

MFG.PART: 24744S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	49
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	COX10 (E6K4D) Rabbit mAb recognizes endogenous levels of total COX10 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp31 of human COX10 protein.
Background	COX10 is an assembly factor for cytochrome c oxidase (COX, also known as complex IV) in the mitochondrial electron transport chain (1,2). Studies show that, when the gene encoding the β2-adrenergic receptor (Adrb2) is deleted, increased oxidative phosphorylation in endothelial cells inhibits angiogenesis. Deletion of Cox10 prevents the metabolic switch to oxidative phosphorylation in endothelial cells deleted of Adrb2, causing angiogenesis and cancer progression (2). In addition, COX10 contributes to T cell quiescence exit and is critical for T cell activation (3).

Specifications