Cell Signaling Pan-Keratin (5d3/Lp34) Mouse mAb

Name: Cell Signaling Pan-Keratin (5d3/Lp34) Mouse mAb
SKU: CSIG-27178S
Price: 365.62 USD

List Price $365.62 Your Price $365.62

Cell Signaling Pan-Keratin (5d3/Lp34) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-27178S

MFG.PART: 27178S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{IHC Leica Bond: 1:200 - 1:800, Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	Pan-Keratin (5D3/LP34) Mouse mAb detects endogenous levels of total keratin 5, 6, 8, and 18.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with cytokeratins for the human breast carcinoma cell line MCF7 for clone 5D3 and for the detergent-insoluble fraction of psoriatic human epidermis for clone LP34.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).

Specifications