Cell Signaling Phospho-(Ser/Thr) Atm/Atr Substrate Antibody

Name: Cell Signaling Phospho-(Ser/Thr) Atm/Atr Substrate Antibody
SKU: CSIG-2851S
Price: 444.40 USD

List Price $444.40 Your Price $444.40

Cell Signaling Phospho-(Ser/Thr) Atm/Atr Substrate Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2851S

MFG.PART: 2851S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:20, Peptide ELISA (DELFIA): 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-(Ser/Thr) ATM/ATR Substrate Antibody detects endogenous levels of proteins containing the ATM/ATR substrate motif. This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic amino acids at the -1 position and followed by Gln at the +1 position. The antibody does not cross-react with corresponding nonphosphorylated sequences or with other phospho-Ser/Thr-containing motifs. (U.S. Patent Nos.: 6,441,140; 6,982,318; 7,259,022; 7,344,714; U.S.S.N. 11,484,485; and all foreign equivalents.)
Species Reactivity	All Species Expected
Source/Purification	Polyclonal antibodies are produced by immunizing animals with synthetic phospho-(Ser/Thr) ATM/ATR substrate peptides . Antibodies are purified by protein A and peptide affinity chromatography.
Background	Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair (1). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1 (1,2) The essential requirement for the substrates of ATM/ATR is S