Cell Signaling Cyclin A2 (E6d1j) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cyclin A2 (E6d1j) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-29113SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cyclin A2 (E6d1j) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-29113SF

MFG.PART: 29113SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #67955
Specificity/Sensitivity	Cyclin A2 (E6D1J) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total cyclin A2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human cyclin A2 protein. The epitope corresponds to a region surrounding Glu121 of human cyclin A2.
Background	While overcoming the G1/S checkpoint to commence DNA replication requires cyclin E, and traversing the G2/M checkpoint to initiate mitosis requires cyclin B to be present, cyclin A seems to be required for both S-phase and M-phase (1). A number of studies have described the ability of overexpressed cyclin A to accelerate the G1 to S transition causing DNA replication, and cyclin A antisense DNA can prevent DNA replication (2-4). Cyclin A availability is apparently the rate-limiting step for entry into mitosis, and cyclin A is required for completion of prophase (5). At late prophase, cyclin A may no longer be necessary as cdc2/cyclinB1 becomes active (5).

Specifications