Cell Signaling Insulin (C27c9) Rabbit mAb

Name: Cell Signaling Insulin (C27c9) Rabbit mAb
SKU: CSIG-3014S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Insulin (C27c9) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3014S

MFG.PART: 3014S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:6400 - 1:25600, Immunofluorescence (Frozen): 1:200 - 1:800, Immunofluorescence (Immunocytochemistry): 1:200 - 1:800, Flow Cytometry (Fixed/Permeabilized): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #56823.
Specificity/Sensitivity	Insulin (C27C9) Rabbit mAb detects endogenous levels of total insulin protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to Val42 of human insulin.
Background	The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).

Specifications