Cell Signaling Gap43 (E1u1d) Mouse mAb

Name: Cell Signaling Gap43 (E1u1d) Mouse mAb
SKU: CSIG-30817S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Gap43 (E1u1d) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-30817S

MFG.PART: 30817S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	38, 43
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Frozen): 1:100 - 1:400, Immunofluorescence (Immunocytochemistry): 1:100 - 1:400}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GAP43 (E1U1D) Mouse mAb recognizes endogenous levels of total GAP43 protein. This antibody detects a non-specific band of unknown origin at 110 kDa.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse GAP43 protein.
Background	GAP43 is a nervous system specific, growth-associated protein enriched in growth cones and areas of high plasticity (1). Phosphorylation of GAP43 at Ser41 by PKC is regulated by intracellular Ca2+ and affects the ability of GAP43 to bind calmodulin (2,3). GAP43 is integral to growth cone formation, neurite outgrowth, and the development of a functional cerebral cortex (4,5). Aberrant GAP43 expression can be seen in patients diagnosed with schizophrenia and Alzheimers Disease (6,7).