Cell Signaling Hnf4alpha (C11f12) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Hnf4alpha (C11f12) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-31059SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Hnf4alpha (C11f12) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-31059SF

MFG.PART: 31059SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	52
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3113
Specificity/Sensitivity	HNF4α (C11F12) Rabbit mAb (BSA and Azide Free) detects endogenous levels of total HNF4α protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser461 of human HNF4α.
Background	Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2,3). Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY) (5).

Specifications