Cell Signaling Pvr/Cd155 (D8a5g) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Pvr/Cd155 (D8a5g) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-31235SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Pvr/Cd155 (D8a5g) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-31235SF

MFG.PART: 31235SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	60-80
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #81254.
Specificity/Sensitivity	PVR/CD155 (D8A5G) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD155 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn188 of human CD155 protein.
Background	Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6).

Specifications