Cell Signaling P14 Arf (E3x6d) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling P14 Arf (E3x6d) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-31426SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling P14 Arf (E3x6d) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-31426SF

MFG.PART: 31426SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	14
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #74560
Specificity/Sensitivity	p14 ARF (E3X6D) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total p14 ARF protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro126 of human p14 ARF protein.
Background	Human p14 ARF (p19 ARF in mouse) is a pro-apoptotic cell cycle regulator frequently inactive in human tumors (1). Basal expression of p14 ARF is low in most cell types, but accumulation of this protein occurs in response to oncogene expression (2,3). Increased p14 ARF levels facilitate MDM2 degradation, leading to increased p53 protein levels and subsequent cell cycle arrest and/or apoptosis (4). While most p14 ARF signaling has traditionally thought to be p53-dependent, more recent reports have described p53-independent p14 ARF signaling leading to cell cycle arrest and apoptosis (5,6).

Specifications