Cell Signaling Lyar (E6h1a) Rabbit mAb

Name: Cell Signaling Lyar (E6h1a) Rabbit mAb
SKU: CSIG-31468S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Lyar (E6h1a) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-31468S

MFG.PART: 31468S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	48
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LYAR (E6H1A) Rabbit mAb recognizes endogenous levels of total LYAR protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LYAR protein.
Background	Ly-1 antibody reactive clone (LYAR) is a zinc finger motif-containing nucleolar protein that is expressed at high levels in male germ cells (1). Research studies have shown LYAR plays a role in the control of embryonic stem cell (ESC) self-renewal and differentiation (2,3). Given its nucleolar localization and oncogenic potential, LYAR has been shown to participate in the regulation of ribosomal gene transcription, rRNA processing, and ribosome biogenesis; processes that many cancer cells and ESCs ramp up in order to support high rates of cell proliferation (4,5). In addition to its role in controlling cell growth and proliferation, LYAR has also been shown to play a role in negatively regulating the host antiviral innate immune response by suppressing the expression of type-I interferons and proinflammatory cytokines (6).