Cell Signaling E2f8 (E8i3l) Rabbit mAb

Name: Cell Signaling E2f8 (E8i3l) Rabbit mAb
SKU: CSIG-34661S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling E2f8 (E8i3l) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-34661S

MFG.PART: 34661S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	105
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:800 - 1:3200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	E2F8 (E8I3L) Rabbit mAb recognizes endogenous levels of total E2F8 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human E2F8 protein.
Background	The E2F family consists of eight transcription factors that regulate gene expression to control cell cycle progression. The atypical E2F family members, E2F-7 and E2F-8, are unique in that they have two distinct DNA-binding domains, but lack the DP-heterodimerization, retinoblastoma-binding, and transcriptional activation domains contained in the canonical E2F family members. E2F-7 and E2F-8 are thought to function primarily as transcriptional repressors (1).E2F8 is highly expressed in multiple human cancers, including hepatocellular carcinoma, lung, breast, ovarian and cervical cancer, and may serve as a prognostic marker (1-5). In cancer cell lines, E2F8 expression enhances proliferation, migration, invasion, and the expression of epithelial mesenchymal transition (EMT) markers (2,3).