Cell Signaling Pan-Keratin (C11) Mouse mAb (Alexa Fluor 555 Conjugate)

Name: Cell Signaling Pan-Keratin (C11) Mouse mAb (Alexa Fluor 555 Conjugate)
SKU: CSIG-3478S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Pan-Keratin (C11) Mouse mAb (Alexa Fluor 555 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3478S

MFG.PART: 3478S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R Mk
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{Immunohistochemistry (Paraffin): 1:50 - 1:200, Immunofluorescence (Immunocytochemistry): 1:50, Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Pan-Keratin (C11) Mouse mAb (Alexa Fluor® 555 Conjugate) detects endogenous levels of total keratins 4, 5, 6, 8, 10, 13 and 18. The antibody does not cross-react with other keratins.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a cytoskeleton preparation from A-431 cells. The antibody was conjugated to Alexa Fluor®555 under optimal conditions with an F/P ratio of 2-6.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).

Specifications