Cell Signaling Plexin A1 Antibody

Name: Cell Signaling Plexin A1 Antibody
SKU: CSIG-3813S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Plexin A1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3813S

MFG.PART: 3813S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H R
Sensitivity	Endogenous
Molecular Weight (kDa)	211
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Plexin A1 Antibody detects endogenous levels of total Plexin A1 protein.
Species Reactivity	Human, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Gln1875 of human Plexin A1. Antibodies are purified by peptide affinity chromatography.
Background	Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3).

Specifications