Cell Signaling Cd11b/Itgam (E6e1m) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cd11b/Itgam (E6e1m) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-41028SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cd11b/Itgam (E6e1m) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-41028SF

MFG.PART: 41028SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	170
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #17800
Specificity/Sensitivity	CD11b/ITGAM (E6E1M) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD11b/ITGAM protein. Nonspecific signal is seen by western blot when testing human spleen tissue extracts.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse CD11b/ITGAM protein.
Background	Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the bloodstream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematosus (SLE) (4).

Specifications