Cell Signaling Il-27ra (E3l6u) Rabbit mAb

Name: Cell Signaling Il-27ra (E3l6u) Rabbit mAb
SKU: CSIG-41220S
Price: 379.76 USD

List Price $379.76 Your Price $379.76

Cell Signaling Il-27ra (E3l6u) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-41220S

MFG.PART: 41220S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	95, 105
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IL-27RA (E3L6U) Rabbit mAb recognizes endogenous levels of total IL-27RA protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human IL-27RA protein.
Background	Interleukin 27 receptor α (IL-27RA or IL-27Rα), also known as T cell cytokine receptor (TCCR) and WSX-1, forms a receptor complex with gp130 to bind and enable IL-27 signaling (1,2). IL-27Rα is expressed on T cells, B cells, natural killer (NK) cells, monocytes, macrophages, dendritic cells (DCs), as well as on subsets of epithelial and endothelial cells (3). Binding of IL-27 to its receptor complex induces the activation of receptor-associated Jak1 and Jak2, which in turn phosphorylates Stat1 and Stat3 (4,5). IL-27 signaling plays an important anti-inflammatory role in chronic immune-mediated disease and infectious disease, and enhances the expression of co-inhibitory molecules LAG-3, TIM-3, PD-1, and TIGIT (6-8). Due to its immunosuppressive role in cancers, IL-27 has been identified as a target for cancer immunotherapy (9).