Cell Signaling Oas3 Antibody

Name: Cell Signaling Oas3 Antibody
SKU: CSIG-41440S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Oas3 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-41440S

MFG.PART: 41440S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	120
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	OAS3 Antibody recognizes endogenous levels of total OAS3 protein. This antibody detects an 18 kDa band of unknown origin in some cell lines.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human OAS3 protein. Antibodies are purified by peptide affinity chromatography.
Background	The 2-5-oligoadenylate synthetase (OAS) family of interferon-induced proteins play an important role in cellular innate immune response (1-4). When activated by double-stranded RNA, these proteins polymerize ATP into 2′-5′-linked oligomers (2,3,5). These 2’-5’-linked oligoadenylates bind to the ribonuclease RNase L, which then degrades viral and cellular RNA (2,3,5). In humans, the OAS family of proteins includes OAS1, OAS2, OAS3, and OASL (1-3). OAS3 is required to activate RNase L and to restrict the replication of four different human viruses (5). These findings suggest that OAS3 may provide a target for antiviral therapies (4,5).