Cell Signaling Lag3 (D2g4o) Xp Rabbit mAb (Biotinylated)

Name: Cell Signaling Lag3 (D2g4o) Xp Rabbit mAb (Biotinylated)
SKU: CSIG-44774S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Lag3 (D2g4o) Xp Rabbit mAb (Biotinylated) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-44774S

MFG.PART: 44774S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	60-80
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 136 mm NaCl, 2.6 mm KCI, 12 mm sodium phosphate (pH 7.4) dibasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LAG3 (D2G4O™) XP® Rabbit mAb (Biotinylated) recognizes endogenous levels of total LAG3 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human LAG3 protein.
Background	Lymphocyte activation gene 3 (LAG-3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region (1). LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs, and NK cells, where its activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells (2), LAG3 can also inhibit CD8+ T cells (3,4). LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to contribute to tumor-mediated immune suppression (4,5). Blockade of LAG3 is a promising strategy for neoplastic intervention (6).