Cell Signaling Mek1 (D2r1o) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Mek1 (D2r1o) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-45307SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Mek1 (D2r1o) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45307SF

MFG.PART: 45307SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	45
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #12671.
Specificity/Sensitivity	MEK1 (D2R1O) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total MEK1 protein. This antibody does not cross-react with MEK2 or other MAPK kinase proteins.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MEK1 protein.
Background	MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.