Cell Signaling Cd20 (E3n7o) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cd20 (E3n7o) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-45839SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cd20 (E3n7o) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45839SF

MFG.PART: 45839SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	30-50
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #70168.
Specificity/Sensitivity	CD20 (E3N7O) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD20 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD20 protein.
Background	B-lymphocyte antigen CD20 (also known as MS4A1; Membrane-spanning 4-domains subfamily A member 1) is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation (1,2). It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse (1-3). Evidence suggests that CD20 is necessary for store operated calcium (SOC) entry, which leads to elevated cytoplasmic calcium levels required for B cell activation (4,5). Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases (6).

Specifications