Cell Signaling Cd11b/Itgam (M1/70) Rat mAb

Name: Cell Signaling Cd11b/Itgam (M1/70) Rat mAb
SKU: CSIG-46512S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Cd11b/Itgam (M1/70) Rat mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-46512S

MFG.PART: 46512S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Source/Isotype	Rat IgG2b kappa
Application/Dilution	{Immunofluorescence (Frozen): 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. This product is stable for 36 months when stored at -20C. Do not aliquot the antibody.
Specificity/Sensitivity	CD11b/ITGAM (M1/70) Rat mAb recognizes endogenous levels of total CD11b/ITGAM protein. This antibody detects an epitope within the extracellular domain.
Species Reactivity	Mouse
Source/Purification	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography.
Background	Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the bloodstream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematosus (SLE) (4).

Specifications