Cell Signaling Fgl1 (E8v9q) Rabbit mAb

Name: Cell Signaling Fgl1 (E8v9q) Rabbit mAb
SKU: CSIG-47507S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Fgl1 (E8v9q) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-47507S

MFG.PART: 47507S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	32
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:200 - 1:800}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	FGL1 (E8V9Q) Rabbit mAb recognizes endogenous levels of total FGL1 protein. This antibody detects a faint cross-reactive band around 27 kDa of unknown identity in some cell extracts.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human FGL1 protein.
Background	FGL1 (fibrinogen-like protein 1, also known as hepassocin) is a secreted protein mainly expressed in liver and its expression is further enhanced following acute liver injury (1-3). FGL1 mice have multiple metabolic abnormalities and are more prone to develop hepatocellular carcinoma under certain experimental conditions, suggesting FGL1 has diverse functions in vivo (4,5). More recently, FGL1 was found to be highly expressed in human cancer cells and function as an inhibitory ligand for LAG3. Blockade of the FGL1-LAG3 interaction stimulates tumor immunity in mouse models. In addition, a high plasma FGL1 level in human cancer patients is associated with a poor prognosis and resistance to anti-PD-1/PD-L1 immunotherapy (6).