Cell Signaling Keratin 14 (Ll002) Mouse mAb

Name: Cell Signaling Keratin 14 (Ll002) Mouse mAb
SKU: CSIG-48020S
Price: 365.62 USD

List Price $365.62 Your Price $365.62

Cell Signaling Keratin 14 (Ll002) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-48020S

MFG.PART: 48020S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG3
Application/Dilution	{IHC Leica Bond: 1:100 - 1:400, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied in a PBS-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	Keratin 14 (LL002) Mouse mAb recognizes endogenous levels of keratin 14 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human keratin 14 protein.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).