Cell Signaling Keratin 7 (R458) Antibody

Name: Cell Signaling Keratin 7 (R458) Antibody
SKU: CSIG-4898S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Keratin 7 (R458) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4898S

MFG.PART: 4898S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Keratin 7 (R458) Antibody detects endogenous levels of total keratin 7 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human keratin 7 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).Keratin 7 and keratin 19 are present in hepatic and pancreatic progenitor/stem cells (7,8).

Specifications