Cell Signaling Taz (E9j5a) Xp® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Taz (E9j5a) Xp® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-49756SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Taz (E9j5a) Xp® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-49756SF

MFG.PART: 49756SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #72804
Specificity/Sensitivity	TAZ (E9J5A) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total TAZ protein. This antibody does not cross-react with YAP protein. Species cross-reactivity for IHC-P is human only.
Species Reactivity	Human, Mouse, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinantly expressed full-length human TAZ protein.
Background	TAZ is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 proteins (1). TAZ shares homology with the WW domain of Yes-associated protein (YAP) (1). TAZ is proposed to modulate the switch between proliferation and differentiation of mesenchymal stem cells (MSC) via interaction with transcription factors Runx2 and PPARγ. This process is critical to normal tissue development and the prevention of tumor formation. Due to its role in determination of MSC fate, TAZ may have clinical relevance to several human diseases caused by an imbalance of MSC differentiation (2,3). TAZ is negatively regulated via phosphorylation by LATS1/2, core kinases in the Hippo signaling pathway that controls stem cell development, tissue growth and tumor development (4).

Specifications