Cell Signaling Cd133 (D2v8q) Xp® Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cd133 (D2v8q) Xp® Rabbit mAb (BSA And Azide Free)
SKU: CSIG-51917SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cd133 (D2v8q) Xp® Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-51917SF

MFG.PART: 51917SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	133
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #64326.
Specificity/Sensitivity	CD133 (D2V8Q) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD133 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the 1st extracellular loop of human CD133 protein. The epitope has been mapped to a region spanning amino acid residues 303-312. This antibody is not sensitive to the glycosylation status of CD133.
Background	CD133, also known as Prominin, was first described as a cell surface marker recognized by monoclonal antibody AC133 on putative hematopoietic stem cells (1). Subsequent cDNA cloning indicated that CD133 is a five-transmembrane protein with a predicted molecular weight of 97 kDa. Due to heavy glycosylation, its apparent molecular weight is 130 kDa as determined by SDS-PAGE analysis (2). Besides blood stem cells, CD133 is expressed on and used to isolate other stem cells, including cancer stem cells (3-7). A deletion mutation in CD133 produces aberrant protein localization and may result in retinal degeneration in humans (8).

Specifications