Cell Signaling Lamp1 (D2d11) Xp Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Lamp1 (D2d11) Xp Rabbit mAb (BSA And Azide Free)
SKU: CSIG-52252SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Lamp1 (D2d11) Xp Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-52252SF

MFG.PART: 52252SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	42 (non-glycosylated), 90-120 (glycosylated)
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #9091.
Specificity/Sensitivity	LAMP1 (D2D11) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total LAMP1 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein fragment of human LAMP1 protein.
Background	Lysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) are two abundant lysosomal membrane proteins (1,2). Both are transmembrane proteins and are heavily glycosylated at the amino-terminal luminal side of the lysosomal inner leaflet, which protects the proteins from proteolysis (3). The carboxy terminus of LAMP1 is exposed to the cytoplasm and contains a tyrosine sorting motif that targets LAMP to lysosomal membranes (4). LAMP1 and LAMP2 are 37% homologous in their protein sequences. Both LAMP1 and LAMP2 are involved in regulating lysosomal motility during lysosome-phagosome fusion and cholesterol trafficking (5,6).