Cell Signaling Pvrig Antibody

Name: Cell Signaling Pvrig Antibody
SKU: CSIG-52671S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Pvrig Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-52671S

MFG.PART: 52671S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	30-40
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PVRIG Antibody recognizes endogenous levels of total PVRIG protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala318 of human PVRIG protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein (PVRIG; also known as CD112 receptor) is a multiple transmembrane protein expressed on the surface of T cells and NK cells, predominantly on memory and effector CD8+ T cells. PVRIG expression is upregulated after in vitro T cell activation with anti-CD3 and anti-CD28 antibodies. PVRIG competes with DNAM-1/CD226 for interaction with the receptor ligand Nectin-2. Upon ligation of PVRIG and Nectin-2, T cell proliferation is inhibited, suggesting PVRIG is a co-inhibitory receptor that dampens T cell functions (1).

Specifications