Cell Signaling Cd10/Neprilysin (E5p7s) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cd10/Neprilysin (E5p7s) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-54370SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Cd10/Neprilysin (E5p7s) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54370SF

MFG.PART: 54370SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #65534.
Specificity/Sensitivity	CD10/Neprilysin (E5P7S) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CD10/Neprilysin protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human CD10/Neprilysin recombinant protein.
Background	CD10, also known as neprilysin, common acute lymphoblastic leukemia antigen (CALLA), or neutral endopeptidase (NEP), is a zinc-dependent transmembrane metallo-endopeptidase. CD10 cleaves peptides at the N-terminal side of hydrophobic amino acid residues and deactivates a variety of signaling peptides (1-2). CD10 was shown to be one of the markers for a natural killer cell-restricted progenitor in fetal and adult tissues (3). Studies also suggest CD10 as a phenotypic marker to distinguish mature neutrophils from immature neutrophils in patients with inflammation (2). In addition, CD10+GPR77+ carcinoma-associated fibroblasts (CAFs) promote tumor formation and chemoresistance (4).

Specifications