Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-54382SF
Price: 884.76 USD

List Price $884.76 Your Price $884.76

Cell Signaling Phospho-Tbk1/Nak (Ser172) (D52c2) Xp Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54382SF

MFG.PART: 54382SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	84
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #5483
Specificity/Sensitivity	Phospho-TBK1/NAK (Ser172) (D52C2) XP® Rabbit mAb (BSA and Azide Free) detects endogenous levels of TBK1 only when phosphorylated at Ser172. This antibody may cross-react with phospho-IKKε.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is prepared from animals immunized with a synthetic phosphopeptide corresponding to residues surrounding Ser172 of human TBK1.
Background	TBK1 (TANK-binding kinase 1)/NAK (NF-κB activating kinase) is an IκB kinase (IKK)-activating kinase and can activate IKK through direct phosphorylation (1). TBK1 was identified through association with the TRAF binding protein, TANK, and found to function upstream of NIK and IKK in the activation of NF-κB (2). TBK1 induces IκB degradation and NF-κB activity through IKKβ. TBK1 may mediate IKK and NF-κB activation in response to growth factors that stimulate PKCε activity (1). TBK1 plays a pivotal role in the activation of IRF3 in the innate immune response (3).TBK1 is phosphorylated at Ser172 within its activation loop, which is necessary of its kinase activity including the downstream phosphorylation of IRF3 (4,5).

Specifications