Cell Signaling Cd80 (E6j6n) Rabbit mAb

Name: Cell Signaling Cd80 (E6j6n) Rabbit mAb
SKU: CSIG-54521S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Cd80 (E6j6n) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54521S

MFG.PART: 54521S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	50-75
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD80 (E6J6N) Rabbit mAb recognizes endogenous levels of total CD80 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with mouse CD80 recombinant protein.
Background	CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).