Cell Signaling Cytochrome B (E7f8z) Rabbit mAb

Name: Cell Signaling Cytochrome B (E7f8z) Rabbit mAb
SKU: CSIG-54618S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Cytochrome B (E7f8z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54618S

MFG.PART: 54618S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	26
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cytochrome b (E7F8Z) Rabbit mAb recognizes endogenous levels of total cytochrome b protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro208 of human cytochrome b protein.
Background	Cytochrome b, encoded by the gene MT-CYB, is a subunit of ubiquinol-cytochrome c reductase, also known as cytochrome bc1, or complex III, of the mitochondrial respiratory (electron transport) chain (1). This protein complex mediates electron transfer from ubiquinol to cytochrome c, contributing to the generation of a proton gradient that powers ATP synthesis (2). Cytochrome b is an integral membrane protein and notable for being the only protein within complex III that is encoded by the mitochondrial genome. Genetic sequence analyses have identified mutations in MT-CYB that are linked to a variety of diseases and pathologies (3,4). Natural variations in the sequence of MT-CYB have also proven highly useful as a tool to determine phylogenetic relationships between organisms (5).

Specifications