Cell Signaling Androgen Receptor Antibody (Carboxy-Terminal Antigen)

Name: Cell Signaling Androgen Receptor Antibody (Carboxy-Terminal Antigen)
SKU: CSIG-54653S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Androgen Receptor Antibody (Carboxy-Terminal Antigen) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-54653S

MFG.PART: 54653S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	110
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Androgen Receptor Antibody (Carboxy-terminal Antigen) recognizes endogenous levels of total Androgen Receptor protein. This antibody does not detect AR-V7 isoform.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val662 of human Androgen Receptor protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).