Cell Signaling Insulin (C27c9) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Insulin (C27c9) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-56823SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Insulin (C27c9) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-56823SF

MFG.PART: 56823SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3014
Specificity/Sensitivity	Insulin (C27C9) Rabbit mAb (BSA and Azide Free) detects endogenous levels of total insulin protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to Val42 of human insulin.
Background	The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).