Cell Signaling Whitlow/218 Linker (E3u7q) Rabbit mAb

Name: Cell Signaling Whitlow/218 Linker (E3u7q) Rabbit mAb
SKU: CSIG-57710T
Price: 212.10 USD

List Price $212.10 Your Price $212.10

Cell Signaling Whitlow/218 Linker (E3u7q) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-57710T

MFG.PART: 57710T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	All
Sensitivity	Transfected Only
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Live): 1:100 - 1:400}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #66159.
Specificity/Sensitivity	Whitlow/218 Linker (E3U7Q) Rabbit mAb recognizes exogenously expressed levels of scFv-based CARs containing a Whitlow/218 linker.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues of the Whitlow/218 linker peptide.
Background	The Whitlow/218 peptide is a commonly used linker that connects the variable heavy (VH) domain and variable light (VL) domain of single-chain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The Whitlow/218 linker affords the scFv with enhanced resistance to proteolysis and aggregation (1).

Specifications