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Cell Signaling Sars-Cov-2 Nsp1 Antibody
List Price
$320.17
Your Price
$320.17
Cell Signaling Sars-Cov-2 Nsp1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-57896S
MFG.PART:
57896S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | Vir |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 20-25 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SARS-CoV-2 Nsp1 Antibody recognizes endogenous levels of total SARS-CoV-2 Nsp1 protein in infected cells. |
| Species Reactivity | Virus |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala76 of SARS-CoV-2 Nsp1 protein. Antibodies are purified by peptide affinity chromatography. |
| Background | The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), 9 accessory proteins, and 4 canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N) (2). Nsp1 is the first protein to be translated from the viral RNA by the eukaryotic translational machinery. It has previously been shown that Nsp1 from SARS-CoV inhibits the host response to viral RNA by inhibiting host cell translation including mRNA encoding Type 1 interferon (3). The ability of SARS-CoV-2 Nsp1 has also been shown to exert inhibition of host cell translation, specifically by binding to the 40S ribosomal subunit, and competing out entry of M7G capped eukaryotic mRNA to the entry channel of the pre-initiation translation complex (4,5). |
| SKU | CSIG-57896S |
|---|---|
| Supplier Part Number | 57896S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |