Cell Signaling Lox (D8f2k) Rabbit mAb

Name: Cell Signaling Lox (D8f2k) Rabbit mAb
SKU: CSIG-58135S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Lox (D8f2k) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-58135S

MFG.PART: 58135S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	54, 56
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LOX (D8F2K) Rabbit mAb recognizes endogenous levels of total LOX protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the human LOX protein.
Background	LOX (lysyl oxidase) is a secreted copper-dependent amine oxidase and a member of the lysyl oxidase family (1). It primarily catalyzes the oxidation of lysine (or hydroxylysine) residues in collagen and elastin to form peptidyl aldehyde derivatives (2). These modifications are required for further cross-linking of target proteins to enhance ECM (extracellular matrix) stiffness. LOX plays critical roles in vascular, lung, and skin development, and tissue damage repair (3-5). Upregulation of LOX is associated with various diseases, including cancer progression and tissue fibrosis. Aberrant LOX activity creates a favorable tumor microenvironment to promote tumor metastasis and distal colonization (6-8).