Cell Signaling Fcgammariia (E3k8u) Rabbit mAb

Name: Cell Signaling Fcgammariia (E3k8u) Rabbit mAb
SKU: CSIG-60432S
Price: 379.76 USD

List Price $379.76 Your Price $379.76

Cell Signaling Fcgammariia (E3k8u) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-60432S

MFG.PART: 60432S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	40-50
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	FcγRIIA (E3K8U) Rabbit mAb recognizes endogenous levels of total FcγRIIA protein. This antibody does not cross-react with FcγRIIB protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro170 of human FcγRIIA protein.
Background	FcγRIIA (CD32A) is a low affinity, IgG Fc-binding receptor belonging to the immunoglobulin receptor superfamily (1-3). In humans, it is expressed on myeloid cells, dendritic cells, and platelets (2-4). FcγRIIA is an activating-type Fc receptor, and signals through an immunoreceptor tyrosine-based activation motif (ITAM) present on its own IgG binding chain (2-4). ITAM signaling is essential for FcγRIIA-dependent phagocytosis and the induction of cytokine secretion (3). In addition to binding to IgG, FcγRI and FcγRII also bind to pentraxin proteins of the innate immune system (5).