Cell Signaling Cox1/Mt-Co1 Antibody

Name: Cell Signaling Cox1/Mt-Co1 Antibody
SKU: CSIG-62101S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Cox1/Mt-Co1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-62101S

MFG.PART: 62101S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	32
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	COX1/MT-CO1 Antibody recognizes endogenous levels of total COX1/MT-CO1 protein. This antibody does not cross-react with COX2/MT-CO2 protein or COX3/MT-CO3 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COX1/MT-CO1 protein. Antibodies are purified by peptide affinity chromatography.
Background	The mitochondrial electron transport chain comprises multiple protein complexes including cytochrome c oxidase. Cytochrome c oxidase catalyzes the reduction of oxygen to water. This process is coupled with pumping protons from the mitochondrial matrix into mitochondrial intermembrane space, contributing to the proton gradient used for ATP synthesis (1). Cytochrome c oxidase consists of 3 mitochondrial DNA-encoded subunits (COX1/MT-CO1, COX2/MT-CO2, and COX3/MT-CO3) and multiple nuclear DNA-encoded subunits (2). Research studies show that the mRNAs of the mitochondrially encoded oxidative phosphorylation subunits, including COX1/MT-CO1, decline significantly during aging (3).

Specifications