Cell Signaling Phospho-Stat1 (Ser727) (D3b7) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Phospho-Stat1 (Ser727) (D3b7) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-62390SF
Price: 906.98 USD

List Price $906.98 Your Price $906.98

Cell Signaling Phospho-Stat1 (Ser727) (D3b7) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-62390SF

MFG.PART: 62390SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	91
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #8826
Specificity/Sensitivity	Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of Stat1 protein only when phosphorylated at Ser727.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser727 of human Stat1 protein.
Background	The Stat1 transcription factor is activated in response to a large number of ligands (1) and is essential for responsiveness to IFN-α and IFN-γ (2,3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding (4). Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa). In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors (5). In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-α and other cellular stresses (6). Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.