Cell Signaling Ki-67 (D2h10) Rabbit mAb (Alexa Fluor ® 488 Conjugate)

Name: Cell Signaling Ki-67 (D2h10) Rabbit mAb (Alexa Fluor ® 488 Conjugate)
SKU: CSIG-63273S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Ki-67 (D2h10) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-63273S

MFG.PART: 63273S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:100 - 1:400}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Ki-67 (D2H10) Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total Ki-67 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the amino terminus of human Ki-67 protein.
Background	Ki-67, named after the location where it was discovered (Kiel University, Germany), is a nuclear nonhistone protein (1) that is universally expressed among proliferating cells and absent in quiescent cells (2). Ki-67 detects proliferating cells in G1, S, G2, and mitosis, but not in the G0 resting phase. Research studies have shown that high levels of Ki-67 are associated with poorer breast cancer survival (3). Research studies have explored the use of Ki-67, along with other markers, as potential prognostic or predictive markers in breast cancer and other malignant diseases (4).

Specifications