Cell Signaling Bip (C50b12) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Bip (C50b12) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-63411SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Bip (C50b12) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-63411SF

MFG.PART: 63411SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	78
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3177
Specificity/Sensitivity	BiP (C50B12) Rabbit mAb (BSA and Azide Free) detects endogenous levels of total BiP protein.
Species Reactivity	Human, Mouse
Source/Purification	BiP (C50B12) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gly584 of human BiP.
Background	Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).

Specifications