Cell Signaling G4s Linker (E7o2v) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling G4s Linker (E7o2v) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-63670SF
Price: 949.40 USD

List Price $949.40 Your Price $949.40

Cell Signaling G4s Linker (E7o2v) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-63670SF

MFG.PART: 63670SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #71645
Specificity/Sensitivity	G4S Linker (E7O2V) Rabbit mAb (BSA and Azide Free) recognizes exogenously expressed levels of scFv-based CARs containing a G4S linker.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide containing three Gly4Ser repeats.
Background	The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect the variable heavy (VH) domain and variable light (VL) domain of single-chain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S)3 or 20-mer (G4S)4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains (1,2).

Specifications