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Cell Signaling Exo1 (E6p2b) Rabbit mAb
List Price
$374.71
Your Price
$374.71
Cell Signaling Exo1 (E6p2b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-63862S
MFG.PART:
63862S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 120 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | EXO1 (E6P2B) Rabbit mAb recognizes endogenous levels of total EXO1 protein. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro377 of human EXO1 protein. |
| Background | Mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. MMR requires recognition of a base mismatch or insertion/deletion loop by a MutS homolog followed by recruitment of a MutL heterodimeric complex consisting of MLH1 and PMS1 (MutL-γ), PMS2 (MutL-α), or MLH3 (MutL-γ). Other factors required for MMR in eukaryotes are EXO1, PCNA, RFC, RPA, DNA polymerases, and DNA ligases (1). In addition to its role in MMR, the nuclease EXO1 functions in DNA double-strand break repair, replication stress response, nucleotide excision repair (NER), and telomere maintenance (2). AMPK phosphorylates EXO1 at Ser746 in response to replication stress and subsequent calcium elevation to avoid replication fork resection (3). Mutations in the EXO1 gene are associated with multiple human cancers (4). |
| SKU | CSIG-63862S |
|---|---|
| Featured | No |
| Supplier Part Number | 63862S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |