Cell Signaling Zcchc3 Antibody

Name: Cell Signaling Zcchc3 Antibody
SKU: CSIG-65321S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Zcchc3 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-65321S

MFG.PART: 65321S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	46
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ZCCHC3 Antibody recognizes endogenous levels of total ZCCHC3 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln17 of human ZCCHC3 protein. Antibodies are purified by peptide affinity chromatography.
Background	ZCCHC3 belongs to the family of CCHC-type zinc-finger proteins (1). It binds to cGAS and acts as a cGAS co-sensor in recognizing double-stranded DNA (dsDNA), therefore, playing an essential role in innate immune response to DNA virus (2). ZCCHC3 was also shown to bind dsRNA and promote the binding of dsRNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) RIG-I and MDA5, playing a critical role in RLR-mediated innate immune response to RNA virus (3).

Specifications