Cell Signaling g-Csf (E9s2e) Rabbit mAb

Name: Cell Signaling g-Csf (E9s2e) Rabbit mAb
SKU: CSIG-65883S
Price: 379.76 USD

List Price $379.76 Your Price $379.76

Cell Signaling g-Csf (E9s2e) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-65883S

MFG.PART: 65883S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	15
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	g-CSF (E9S2E) Rabbit mAb recognizes endogenous levels of total g-CSF protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human g-CSF protein.
Background	Granulocyte colony-stimulating factor (g-CSF) is a hematopoietic cytokine essential for neutrophil development, survival, and egress from bone marrow (1-4). Macrophages and monocytes are the predominant producers of g-CSF (3), and endothelial cells, fibroblasts, and neuronal cells can produce g-CSF in response to inflammatory stimuli (3). g-CSF inhibits apoptosis in neutrophils and neurons (4,5). g-CSF stimulates proliferation and differentiation of neuronal progenitor cells (5). g-CSF binding to g-CSFR induces receptor dimerization and activation of Jak1/2 tyrosine phosphorylation (3,6). Signaling is through Stat3, ERK, p38, and Akt (5,6). Absence of functional g-CSF or its receptor in humans and mice causes neutropenia (7,8).

Specifications