Cell Signaling Map2 (D5g1) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Map2 (D5g1) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-65911SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Map2 (D5g1) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-65911SF

MFG.PART: 65911SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	75, 82, 280
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #8707.
Specificity/Sensitivity	MAP2 (D5G1) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total MAP2 protein. Non-specific labeling of the pancreas and macrophages in mouse liver tissue may be observed by immunofluorescence.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAP2 protein.
Background	Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites (1). Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B (280 and 270 kDa), and low molecular weight MAP2C and MAP2D (70 and 75 kDa). Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. GSK-3 and p44/42 MAP kinase phosphorylate MAP2 at Ser136, Thr1620, and Thr1623 (2,3). Phosphorylation at Thr1620/1623 by GSK-3 inhibits MAP2 association with microtubules and microtubule stability (3).