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Cell Signaling Nat10 Antibody
List Price $320.17 Your Price $320.17
Cell Signaling Nat10 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-66548S
MFG.PART: 66548S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 120 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | NAT10 Antibody recognizes endogenous levels of total NAT10 protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NAT10 protein. Antibodies are purified by peptide affinity chromatography. |
| Background | N-acetyltransferase 10 (NAT10), also known as human N-acetyltransferase-like protein (hALP), is an acetyltransferase which increases telomerase activity through the activation of the TERT promoter (1). NAT10 localizes to the midbody in late phase mitosis to help achieve cytokinesis (2). It has been found that DNA damage can actually increase NAT10-dependent acetylation of alpha-tubulin, resulting in increased stability of the protein (2,3). This increased stability of microtubules has been linked to the sequestration of the nuclear import factor Transportin-1 in the premature aging disease, progeria (4,5). NAT10 can also function as an acetyltransferase for both rRNA and mRNA (6-8). The acetylation of the 18 S rRNA helps in rRNA processing and ribosome biogenesis, and this process can be disrupted by opposing activity of the deacetylase SirT1 in response to stress (6,9). mRNA acetylation by NAT10 plays a role in translation efficiency and mRNA stability (7,8). NAT10 is overexpressed in many different cancer types, making it a good potential therapeutic target (10-12) |
| SKU | CSIG-66548S |
|---|---|
| Supplier Part Number | 66548S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |