Cell Signaling Pgm1 (E2i5g) Rabbit mAb

Name: Cell Signaling Pgm1 (E2i5g) Rabbit mAb
SKU: CSIG-68036S
Price: 379.76 USD

List Price $379.76 Your Price $379.76

Cell Signaling Pgm1 (E2i5g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-68036S

MFG.PART: 68036S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	62
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PGM1 (E2I5G) Rabbit mAb recognizes endogenous levels of total PGM1 protein. This antibody does not cross-react with PGM2 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly279 of human PGM1 protein.
Background	Phosphoglucomutase-1 (PGM1) catalyzes the interconversion of glucose 1-phosphate (g-1-P) and glucose 6-phosphate (g-6-P) in the breakdown and synthesis of glycogen. PGM1 expression is downregulated in hepatocellular carcinoma (HCC), suppressing the glycogen synthesis pathway and increasing glucose entry into glycolysis to support cancer proliferation (1). Studies show that TGF-β1 released by ovarian cancer cells induces p38 MAPK signaling in neighboring cancer-associated fibroblasts (CAFs), releasing cytokines and chemokines from CAFs. These cytokines and chemokines promote glycogen mobilization in ovarian cancer cells, stimulating cancer cell proliferation, invasion, and metastasis. Phosphorylation of Tyr353 on PGM1 is essential for its enzymatic activity and glycogen mobilization induced by CAFs (2).

Specifications